Wenyu Zhang


Zoology 301E, 1101 East 57th Street

Chicago, IL 60637

Phone: 773-834-3567

Email: wyzhang(at)uchicago.edu



Academic Activity and Service

Teaching Assistant for "Genetic Networks in Molecular Evolution", The University of Chicago    04/2014 - 06/2014

Teaching Assistant for "Classics of Evolutionary Genetics", The University of Chicago                04/2015 - 06/2015


Research interest

1) MicroRNA biomarker identification for cancer diagnosis; 

2) Effect of new genes on network evolution




1. Wenyu Zhang, Patrick Landback, Andrea R Gschwend, Bairong Shen and Manyuan Long. New genes drive the evolution of gene interaction networks in the human and mouse genomes. Genome Biology 2015 (in press).

2. Wenying Yan, Lihua Xu, Zhandong Sun, Yuxin Lin, Wenyu Zhang, Jiajia Chen, Shaoyan Hu, Bairong Shen. MicroRNA biomarker identification for pediatric acute myeloid leukemia based on a novel bioinformatics model. Oncotarget. 2015 (In press).

3. Wenyu Zhang, Jin Zang, Xinhua Jing, Zhandong Sun, Wenying Yan, Dongrong Yang, Feng Guo and Bairong Shen. Identification of candidate miRNA biomarkers from miRNA regulatory network with application to prostate cancer. J Transl Med. 2014 Mar 11;12(1):66. doi: 10.1186/1479-5876-12-66.

4. Yan W, Sun M, Hu G, Zhou J, Zhang W, Chen J, Chen B, Shen B. Amino acid contact energy networks impact protein structure and evolution. J Theor Biol. 2014 Apr 1. pii: S0022-5193(14)00179-9. doi: 10.1016/j.jtbi.2014.03.032.

5. Jing Shang, Fei Zhu, Wanwipa Vongsangnak, Yifei Tang, Wenyu Zhang, and Bairong Shen. Evaluation and comparison of multiple aligners for next-generation sequencing data analysis. Biomed Res Int. 2014;2014:309650. doi: 10.1155/2014/309650.

6. Chen J, Zhang D, Zhang W, Tang Y, Yan W, Guo L, Shen B. Clear cell renal cell carcinoma associated microRNA expression signatures identified by an integrated bioinformatics analysis. J Transl Med. 2013 Jul 10;11:169. doi:10.1186/1479-5876-11-169.

7. Wenyu Zhang, Jiajia Chen, Yang Yang, Yifei Tang, Jing Shang, Bairong Shen. A Practical Comparison of De Novo Genome Assembly Software Tools for Next-Generation Sequencing Technologies.PLoS ONE, 2011 6(3): e17915

8. Gan LP, Zhang WY, Niu YS, Xu L, Xi J, Ji MM, Xu SQ. 2010. Construction and application of an electronic spatiotemporal expression profile and gene ontology analysis platform based on the EST database of the silkworm, Bombyxmori. Journal of Insect Science 10:114


Book Chapter                                                        

1. Wenyu Zhang and Bairong Shen. Identification of Cancer MicroRNA Biomarkers Based on miRNA–mRNA Network. Bioinformatics for Diagnosis, Prognosis and Treatment of Complex Diseases. Translational Bioinformatics Volume 4, 2013, pp 153-167.